동국대학교 화학과 차상원 분석화학 연구실
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Publications

2023
Park, J.; Cho, H. S.; Moon, D. H.; Lee, Donghoon; Cha, Sangwon; Lee, S. K.; Yoon, Y. J.; Oh, D.-C.*, “Discovery of New Indolosesquiterpenoids Bearing a N-O Linkage by Overexpression of LuxR Regulator in a Marine Bacterium Streptomyces sp.​", Under Revision.

Lee, K. M.; Han, S. M.; Lee, H.-J.; Kang, M.; Jeong, T. Y.; Son, J.; Min, H.; Cha, Sangwon; Oh, H. B.; Oh, W. K.*; Lee, J.*, “Influence of mobile phase composition on the analytical sensitivity of LC–ESI–MS/MS for the concurrent analysis of bisphenols, parabens, chlorophenols, benzophenones, and alkylphenols", Environmental Research, 2023, 221, 115305.

2022
Cha, Sangwon*; Jun, Gyouwoong; Park, Yougyeong; An, Sung Jun; Lee, Donghoon, “Toward Depth-Resolved Analysis of Plant Metabolites by Nanospray Desorption Electrospray Ionization Mass Spectrometry", Molecules, 2022, 27, 7582.

Im, J. H.; Shin, D.; Ban, Y. H.;  Byun, W. S.; Bae, E. S.; Lee, Donghoon; Du, Y. E.; Cui, J.; Kwon, Y.; Nam, S.-J.; Cha, Sangwon; Lee, S. K.; Yoon, Y. J.; Oh, D.-C.*, “Targeted discovery of an enediyne-derived cycloaromatized compound, jejucarboside A, from a marine Actinomycete", Organic Letters, 2022, 24, 7188-7193.

Lee, S.; Lee, K. M.; Han, S. M.; Lee, H.-J.; Sung, C.; Min, H.; Im, H.; Han, S. B.; Cha, Sangwon; Lee, J.*, “Comprehensive LC-MS/MS method combined with tandem hybrid hydrolysis for multiple exposure assessment of multiclass environmental pollutants", Environmental Research, 2022, 211, 113053.

2021
Shrestha, Sarmila Amatya; Cha, Sangwon*, “Ambient desorption/ionization mass spectrometry for direct solid material analysis", TrAC Trends in Analytical Chemistry, 2021, 144, 116420.

Lee, K. M.; Han, S. M.; Lee, S; Jeong, T. Y.; Kim, H. J.; Min H.; Kim K. H.; Cha, Sangwon; Oh W. K.*; Lee, J.*, “Fluoride-assisted liquid chromatography-tandem mass spectrometry method for simultaneous analysis of propofol and its metabolites without derivatization in urine", Journal of Chromatography A, 2021, 1652, 462360.

​Cha, Sangwon; Oh, E.; Oh,S.; Han, S. B.; Im, H.*, “Development and Verification of a Simultaneous Analytical Method for Whole Blood Metals and Metalloids for Biomonitoring Programs", Journal of Environmental Health Sciences, 2021, 47, 64-77.

Park, Jun Young; Shrestha, Sarmila Amatya; Cha, Sangwon*, “Isomer separation and analysis of amphiphilic polysialogangliosides using reversed-phase LC-MS", Journal of Separation Science, 2021, 44(9), 1824-1832.

Kim, H.; Lee, H.; Kim, D.; Tae, H.; Cha, Sangwon; Kim, D.; Kim, S.*, “Mechanism behind the Paper Spray Chemical Ionization Phenomenon and the Choice of Solvent”, Journal of Mass Spectrometry, 2021, 56(4), e4602.
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Lee, Gwangbin; Cha, Sangwon*, “Depth-dependent chemical analysis of handwritings by nanospray desorption electrospray ionization mass spectrometry”, Journal of the American Society for Mass Spectrometry, 2021, 32, 315-321.

Kal, Youngju; Cha, Sangwon*, “In Situ Separation and Analysis of Lipids by Paper Spray Ionization Mass Spectrometry​”, Molecules, 2021, ​26, 93.

[국내특허 등록] 한상범, 차상원, 김준희, "캐쳐스 전처리를 이용한 모발, 손톱 중 니코틴 대사물질 추출방법", 10-2211890-0000, 2021/01/28.

2020
Moon, K.; Cui, J.; Kim, E.; Riandi, E.; Park, S. H.; Byun, W. S.; Kal, Youngju; ​Park, Jun Young, Hwang, S.; Shin, D.; Sun, J.; Oh, K.-B.; Cha, Sangwon; Shin, J.; Lee, S. K.; Yoon, Y. J.; Oh, D.-C.*, “Structures and Biosynthetic Pathway of Pulvomycins B–D: 22-Membered Macrolides from an Estuarine Streptomyces sp.”, Organic Letters, 2020, 22, 5358-5362.

Kim, J.; Cho, H.-D.; Suh, J. H.; Lee, J.-Y.; Lee, E.; Jin, C. H.; Wang, Y.; Cha, Sangwon; Im, H.; Han, S. B.*, “Analysis of Nicotine Metabolites in Hair and Nails Using QuEChERS Method Followed by Liquid Chromatography–Tandem Mass Spectrometry”, Molecules, 2020, 25, 1763.

An, J.; Kim Y.-Y.; Cho, H.-D.; Kim, J.; Lee, J.-Y.; Lee, Y.; Jo, E.-J.; Lee, J.; Cha, Sangwon; Han, S. B.*, “Development and investigation of a QuEChERS-based method for determination of phthalate metabolites in human milk”, Journal of Pharmaceutical and Biomedical Analysis, 2020, 181, 113092.

Cho, H.-D.; Kim, J.; Lee, J.-Y.; Kim, Y.-Y.; Lee, Y.; Jo, E.; Suh, J. H.; Lee, J.; ​Cha, Sangwon; Han, S. B.*, “A novel dried blood spots analysis combined with on-spot reaction for determination of trimethylamine N-oxide and its related compounds”, Talanta, 2020, 210, 120639.

Choi, Soobin; Cha, Sangwon*, “Investigation of Reactions Between Isothiazolinones and Cysteamine by Reactive Paper Spray Ionization Mass Spectrometry (Reactive PSI MS)", Bulletin of the Korean Chemical Society, 2020, 41, 48-53.

Kwon, J.; Park, J.-S.; Kang, M.; Choi, Soobin; Park, J.; Kim, K. T.; Lee, C.; Cha, Sangwon; Rhee, H.-W.*; Shim, S.-H.*, “Bright Ligand-activatable Fluorescent Protein for High-quality Multicolor Live-cell Super-resolution Microscopy",  Nature Communications, 2020, 11, Article number 273.

​Jia, Y.; Li, S.; Ma, H. X.; Gao, J.; Zhu, G.; Zhang, F.; Park, Jun Young;  Cha, Sangwon; Bae, J.-S.; Liu C., “Oxygen vacancy rich Bi2O4-Bi4O7-BiO2-x composites for UV-vis-NIR activated high efficient photocatalytic degradation of bisphenol A", Journal of Hazardous Materials, 2020, 382, 121121.

~2019
Cho, Y. M.; Yang, M.; Im, H.; Cha, Sangwon; Lee, J.; Kim, K. H.; Han, S. B., “Development and Validation of the Simultaneous Analytical Method of Urinary Metals and Metalloids for the National Biomonitoring Programs", Journal of Environmental Health Sciences, 2019, 45, 594-604.
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Lee, Yujin; Seo, Eunii; Park, Jun Young; Bae, K.-H.; Lee, J.; Cha, Sangwon*, “Multi-class Analysis of Exposure Chemicals in Deciduous Teeth by Liquid Chromatography-Mass Spectrometry: Preliminary Studies on Sample Preparation Methods", Mass Spectrometry Letters, 2018, 9, 110-114.
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Kim, D.; Ha, S. Y.; An, J. G.; Cha, Sangwon; Yim U. H.; Kim, S.*, “Estimating Degree of Degradation of Spilled Oils Based on Relative Abundance of Aromatic Compounds Observed by Paper Spray Ionization Mass Spectrometry", Journal of Hazardous Materials, 2018, 359, 421-428.
​
Song, I.; Lee, J.-U.; Baek, J.; Cha, Sangwon; Han S. Y.; Oh, H. B.*, “Free Radical Initiated Peptide Sequencing Using MALDI-TOF/TOF Mass Spectrometry", ​Mass Spectrometry Letters, 2018, 9, 56-60.

Yun, S. H.; Jho, E. H.; Jeong, S.; Choi, Soobin; Kal, Youngju; Cha, Sangwon, “Photodegradation of tetracycline and sulfathiazole individually and in mixtures", ​Food and Chemical Toxicology, 2018, 116, 108-113.

Cha, E.; Jeong, E.S.; Han, S. B.; Cha, Sangwon; Son, J.; Kim, S.; Oh, H.; Lee, J.*, “Ionization of Gas-Phase Polycyclic Aromatic Hydrocarbons in Electrospray Ionization Coupled with Gas Chromatography​", Analytical Chemistry, 2018, 90, 4203-4211.

Shin, Eunbi; Cha, Sangwon*, “In Situ Probing Citrullinated Sites in a Peptide by Reactive Desorption Electrospray Ionization Mass Spectrometry (Reactive DESI MS)", Bulletin of the Korean Chemical Society, 2018, 1, 40-44
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Lee, Yujin; Seo, Eunji; Park, Tae-Min; ​Bae, K.-H.; Cha, Sangwon*, “Analysis of lipids in deciduous teeth by matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS)", Mass Spectrometry Letters, 2017, 8, 105-108.

​Jeong, E.S.; Cha, E.; Cha, Sangwon; Kim, S.; Oh, H.; Kwon, O.-S.; Lee, J.*, “Online Simultaneous Hydrogen/Deuterium Exchange of Multi-Target Gas-Phase Molecules by Electrospray Ionization Mass Spectrometry Coupled with Gas Chromatography", Analytical Chemistry, 2017, ​89, 12284-12292.

Kim, D.;Yim U.H.; Kim B.;Cha, Sangwon*; Kim, S.*, “Paper Spray Chemical Ionization: Highly Sensitive Ambient Ionization Method for Low- and Nonpolar Aromatic Compounds", Analytical Chemistry, 2017, 89, 9056-9061.

Cha, E.; Jeong E.S.;Cha, Sangwon; Lee, J.*, “Coupling of gas chromatography and electrospray ionization high resolution mass spectrometry for the analysis of anabolic steroids as trimethylsilyl derivatives in human urine", Analytica Chimica Acta, 2017, 964, 123-133.

Jia, Y.; Liu, J.; Cha, Sangwon; Choi, Soobin; Park Y. C.; Liu C.*, “Magnetically separable Au-TiO2/nanocube ZnFe2O4 composite for chlortetracycline removal in wastewater under visible light", Journal of Industrial and Engineering Chemistry, 2017, 47, 303-314.

[국내특허 등록] 차상원, 허성, 이광빈, 배상은, "대사 지문용 재료 및 이의 제조방법", 10-1720608-0000, 2017/03/28.

[국내특허 등록] 차상원, 김푸름, "페이퍼 콘 팁 및 이를 이용한 페이퍼 콘 스프레이 이온화 질량분석 방법", 10-1771498-0000, 2017/08/25.

Jun, Gyuwoong; Park, Tae-Min; Cha, Sangwon*, “ Fast and Simple Chemical Fingerprinting Analysis of Medical Herbs by Paper Cone Spray Ionization Mass Spectrometry", Bulletin of the Korean Chemical Society,  2016, 37(8), 1337-1343.
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Human, Z.R.; Moon, K.; Bae, M.; de Beer, Z.W.; Cha, Sangwon; Wingfield, M. J.; Slippers, B.; Oh, D.-C.*; Venter, S.N.*, “ Antifungal Streptomyces spp. Infructescences of Protea spp. in South Africa", Frontiers in Microbiology,  2016, 7, article 1657.
​
Jeong, E.S.; Kim, K.H.; Cha, E.; Kwon, O.-S.; Cha, Sangwon; Lee, J.*, “ Direct and rapid quantification of ephedrines in human urine by paper spray ionization/high resolution mass spectrometry", Journal of Chromatography B,  2016, 1028, 237-241.
​
Park, Woojin; Dongkun Lee; Cha, Sangwon*, “Differentiation of Ganglioside Isomers by MALDI Tandem Mass Spectrometry with Alkali Earth Metal Additives", Bulletin of the Korean Chemical Society,  2015, 36(9), 2272-2277.

Kim, Purum; Cha, Sangwon*, “Paper cone spray ionization mass spectrometry (PCSI MS) for simple and rapid analysis of raw solid samples" Analyst, 2015, 140(17), 5868-5872.

Lee, Gwangbin; Bae, S.-E.; Huh, S.; Cha, Sangwon*, “Graphene oxide embedded sol-gel (GOSG) film as a SALDI MS substrate for robust metabolite fingerprinting" RSC Advances, 2015, 5(70), 56455-56459.

Liu, Z.; Dai, S.; Bones, J.; Ray, S.; Cha, Sangwon; Li, J.-J.; Wilson, L.; Hinckle, G.;  Rossomando, A.; Karger, B. L., “A quantitative proteomic analysis of cellular responses to high glucose media in chinese hamster ovary (CHO) cells" Biotechnology Progress, 2015, 31(4), 1026-1038.

Shin, Eunbi; Cha, Sangwon*, “Comparison of MALDI and ESI for Relative Quantification of Citrullination via Skewed Isotopic Distribution Patterns", Bulletin of the Korean Chemical Society, 2015, 36(5),1373-1377.

Lee, Dongkun; Cha, Sangwon*, “5-Methoxysalicylic acid matrix for ganglioside analysis with matrix-assisted laser desorption/ionization mass spectrometry" Journal of the American Society for Mass Spectrometry, 2015, 26(3), 522-525.

Yoon, D.; Lee, Dongkun; Lee, J.-H.; Cha, Sangwon*; Oh, H. B.*, “Quantitative analysis of polyhexamethylene guanidine (PHMG) oligomers via MALDI-TOF mass spectrometry with an ionic-liquid matrix" Rapid Communications in Mass Spectrometry, 2015, 29(2), 213-219.

Son, Jeongjin; Lee, Gwangbin, Cha, Sangwon*, “Direct Analysis of Triacylglycerols from Crude Lipid Mixtures by Gold Nanoparticle-Assisted Laser Desorption/Ionization Mass Spectrometry" , Journal of the American Society for Mass Spectrometry, 2014, 25, 891-894.

Son, Jeongjin;  Cha, Sangwon*, “ MALDI Mass Spectrometric Analysis of Nonderivatized Steroids Using Cyclodextrin-supported 2,5-Dihydroxybenzoic Acid as Matrix", Bulletin of the Korean Chemical Society, 2014, 35(5), 1409-1412.

Cha, Sangwon*, “Silver-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of Cholesterol Derivatives”, Journal of Basic Sciences, HUFS, 2013, 36, 81-88.

Lee, Gwangbin; Son, Jeongjin; Cha, Sangwon*, “Selective or Class-wide Mass Fingerprinting of Phosphatidylcholines and Cerebrosides from Lipid Mixtures by MALDI Mass Spectrometry”, Bulletin of the Korean Chemical Society, 2013, 34(7), 2143-2147.

Choi, M.; Song J.-S.; Kim, H.-J.; Cha, Sangwon; Lee, E. Y., “MALDI-TOF MS Identification of Peptide Citrullination Site Using Br Signature”, Analytical Biochemistry, 2013, 437(1), 62-67.

Imielinski, M. B.; Cha, Sangwon; Rejtar, T.; Richardson, E. A.; Karger, B. L.; Sgroi, D. C., “Integrated proteomic, transcriptomic, and biological network analysis of laser capture microdissected breast carcinoma reveals molecular features of tumorigenesis and relapse”, Molecular & Cellular Proteomics, 2012, 11, M111.014910.

Thakur, D.; Rejtar, T.; Wang, D.;Bones, J.; Cha, Sangwon; Clodfelder-Miller, B.; Richardson, E.; Binns, S.; Dahiya, S.; Sgroi, D.; Karger, B.L., "Microproteomic analysis of 10,000 laser captured microdissected breast tumor cells using short-range sodium dodecyl sulfate-polyacrylamide gel electrophoresis and porous layer open tubular liquid chromatography tandem mass spectrometry", Journal of chromatography. A, 2011, 1218(45), 8168-8174.

Szymanski, D. W.; Papanastasiou, M.; Melchior, K.; Zvonok, N.; Mercier, R. W.; Janero, D. R.; Thakur, G. A.; Cha, Sangwon; Wu, B.; Karger, B. L.; Makriyannis, A., "Mass spectrometry-based proteomics of human cannabanoid receptor 2: covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation.", Journal of Proteome Research, 2011, 10(10), 4789-4798. 

Cha, Sangwon;Imielinski, M. B.; Rejtar, T.; Richardson, E. A.; Thakur, D.; Sgroi, D. C.; Karger, B. L., “In Situ Proteomic Analysis of Human Breast Cancer Epithelial Cells Using Laser Capture Microdissection (LCM)-LC/MS: Annotation by Protein Set Enrichment Analysis (PSEA) and Gene Ontology (GO)”, Molecular & Cellular Proteomics, 2010, 9(11), 2529-2544.

Perdian, D. C.*; Cha, Sangwon*;Oh, J.; Sakaguchi, D. S.;Yeung, E. S.; Lee, Y. J., “In Situ Probing of Cholesterol in Astrocytes at the Single Cell Level using Laser Desorption Ionization Mass Spectrometric Imaging with Colloidal Silver”, Rapid Communications in Mass Spectrometry, 2010, 24(8), 1147–1154. (*: equal authors)

Cha, Sangwon;Song, Z.; Nikolau, B.; Yeung, E. S., “Direct Profiling and Imaging of Epicuticular Waxes on Arabidopsis thaliana by Laser Desorption/Ionization Mass Spectrometry using Silver Colloid as a Matrix”, Analytical Chemistry, 2009, 81(8), 2991–3000. 

Cha, Sangwon;Zhang, H.; Ilarslan, H. I.; Wurtele, E. S.; Brachova, L.; Nikolau, B. J.; Yeung, E. S., “Direct Profiling and Imaging of Plant Metabolites on Intact Tissues by Using Colloidal Graphite-Assisted Laser Desorption Ionization (GALDI) Mass Spectrometry”, The Plant Journal, 2008, 55 (2), 348–360. 

Zhang, H.; Cha, Sangwon; Yeung, E. S., “Colloidal Graphite-Assisted Laser Desorption//Ionization Mass Spectrometry and MSn of Small Molecules. 2. Direct Profiling and MS Imaging of Small Metabolites from Fruits”, Analytical Chemistry, 2007, 79 (17), 6575–6584. 

Cha, Sangwon; Yeung, E. S., “Colloidal Graphite-Assisted Laser Desorption/Ionization Mass Spectrometry and MSn of Small Molecules. 1. Imaging of Cerebrosides Directly from Rat Brain Tissue”, Analytical Chemistry, 2007, 79 (6), 2373–2385.

Cha, Sangwon; Kim, H.-J., “Analysis of folate by matrix-assisted laser desorption/ionization time–of-flight mass spectrometry”,Bulletin of the Korean Chemical Society, 2003, 24 (9), 1308–1312. 

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